The Carl J. Shapiro Institute for Education and Research at Harvard Medical School and Beth Israel Deaconess Medical Center and the Josiah Macy Jr. Foundation, in partnership with the Association of American Medical Colleges,  request applications from medical schools and affiliated teaching hospitals wishing to participate in Millennium Conference 2025. This conference will examine the present and future uses of artificial intelligence (AI) in medicine and the impact of this technology on medical education. The goal, ultimately, is to prepare medical educators to not only meet the challenges and maximize the potential of AI, but to harness the tool to increase efficiency of teaching and assessment and to identify those elements of a physician’s responsibilities that should not be delegated to the computer while ensuring that we prepare current medical students for an uncertain future of clinical practice.